Scientist I, Pharmacology
This position is for a highly motivated and independent in vitro electrophysiologist to work within a growing electrophysiology laboratory at Biogen Idec. As a member of the Neurology Research department you will design and execute electrophysiology experiments to support the discovery of novel drug targets and the development of small and large molecule drugs for the treatment of neurodegenerative diseases (e.g. Neuropathic pain, Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis). You will work in a fast paced, highly collaborative team environment and will be expected to contribute to projects in various stages of the drug discovery process.
The primary responsibilities of the scientist 1 include:
• Contributing to teams involved in the development of novel drug candidates as an effective and collaborative team member, ensuring timely delivery of team goals at various stages of the drug discovery process (target identification, target validation, lead identification, lead optimization and support of development candidates).
• Designing and executing experimental research related to the identification and validation of new therapeutic targets in neurodegenerative disease including experiments to elucidate the role of drug targets in disease pathophysiology.
• Staying on top of internal and external scientific knowledge and developments in neurodegenerative diseases and drug discovery and integrating that knowledge into ongoing drug discovery efforts.
• Collaborating with members from other groups within and outside of the Neurology Research department such as Medicinal Chemistry, Protein Chemistry, Drug Metabolism, Experimental Medicine, Translational Medicine, etc.
• The candidate is expected to spend approximately 90% of their time in direct experimentation.
• Broad knowledge of state-of-the-art in vitro electrophysiological recording techniques in rodents (patch clamp and field recordings).
• Basic understanding of pharmacology
• Demonstrated ability to work and excel in a collaborative environment
• Excellent verbal and written communication skills
• Ability to develop research strategies and to translate those strategies into concrete plans and actions
• Strong publication record
• Candidates with experience in pain research and/or spinal cord recordings will be preferred.
• Expertise in the biology and pathophysiology of neurodegenerative diseases (e.g. Neuropathic pain, AD, PD, MS, ALS)
• Broad understanding of systems neuroscience
• Basic in vivo electrophysiology skills, willingness to work in vivo
Ph.D. in Neuroscience, Physiology, Pharmacology, or Biophysics
At least 3 years of postdoctoral research experience.