Scientist, Virology / Cell Biology
Scientist, Virology / Cell Biology
Location : Cambridge MA
The Biology department is seeking an exceptional and highly motivated scientist to join a team focused on the discovery and validation of novel drug targets. Current efforts of this team are largely directed to support discovery and development of novel anti-HCV drugs, investigate viral resistance. Future efforts may include mechanistic studies on the resistance of cancer cells to therapeutic agents.
The individual; will be responsible for running mechanism of action studies of Idenix compounds for HCV as well as characterizing cellular polymerase and kinase targets. Will work across all current and future viral targets. Utilizes skills in biochemistry, enzymology, cell biology and possible cancer biology in support of target identification/validation and compound screening activities. This includes the development of assays using purified proteins, cultured cells or biochemical assays using polymerases, proteases, integrase, phosphodiesterases and kinases. Preferred qualifications include experience conducting and managing in vitro cell based studies with multiple phenotypic endpoints, demonstrated mastery of qRT-PCR, to investigate new approaches and/or pathways to target infectious disease. Specifically the candidate will evaluate both direct antiviral approaches as well as targeting host pathways for the prevention or treatment of viral infection. The candidate will utilize in vitro models of viral infection and other tools to evaluate new targets such as translational studies. In addition, the candidate will evaluate the utility of microorganisms as therapeutic agents
Major Duties and Responsibilities include:
• Propagate viruses in cell culture and evaluate their growth characteristics in vitro
• Evaluate the susceptibility of viruses, including clinical isolates, to small molecule inhibitors of viral targets or host targets.
• Conduct studies to understand mechanism-of-action of inhibitors.
• Interact and collaborate with other areas of Research and Development to progress projects into clinical studies.
• Interface research activities with multiple therapeutic areas and functional areas outside of Research.
• Work regularly in the lab with other scientists in the group.
• May involve initiating external collaborations to progress targets.
• Supervise research associates
Knowledge, Skills, and Ability
The position requires a Ph.D. plus 4-8 years of relevant post-doctoral research experience. The successful applicant, with relevant experience in academia and/or industry, will have broad experience and expertise in the areas of virology and/or cancer cell biology, and a strong and consistent track record of research productivity, as demonstrated by high-impact publications. Outstanding written and oral communication skills are essential.
Idenix offers an excellent benefits package including competitive salary, equity compensation, major medical insurance, dental insurance, 401(k) plan participation, and group life and disability insurance.
To be considered for this position, please send your resume by email to firstname.lastname@example.org, or by mail to:
320 Bent Street, 4th Floor
Cambridge, MA 02141
Idenix Pharmaceuticals, Inc. is engaged in the discovery and development of drugs for the treatment of human viral and other infectious diseases. Building on its expertise in nucleoside chemistry and other small molecule chemistry and biology, the company is well positioned to compete in the antiviral pharmaceutical space Idenix’ s current focus is on the treatment of hepatitis C virus (HCV) infections. The company has previously discovered and developed antivirals for the treatment of hepatitis B virus (HBV) and HIV/AIDS.