Production Associate, mRNA Synthesis Purification (1st Shift)

Moderna Therapeutics

Process Development

July 30, 2014

The production group is looking for an experienced associate-level individual with knowledge and experience with preparative/purification chromatography following GLPs with respect to safety, materials, processes, product, data and records.


  • Work intimately with Process Development Team to optimize, clarify and document purification procedures for effectiveness, control, traceability, clarity and efficiency while considering impact to cost, quality and quantity.
  • Assist in the development and implementation of QA systems and controlled procedures while owning those pertaining to production processes.
  • Perform production of modified mRNA for in vitro and in vivo experiments, at both small and large scale, using preparative chromatography procedures to purify mRNA.
  • Follow and establish protocols, improvements to such, allowing for clear and accurate documentation of data, results, and any deviations.
  • Work in a team environment, in a safe and controlled manner, actively participating in frequent production update meetings and staff meetings.

Minimum Qualifications:

  • BS degree in biology, biochemistry or molecular biology.
  • Molecular biology experience, including but not limited to: nucleic acid purification, PCR, gel electrophoresis, column purification, basic laboratory equipment and procedures. 
  • Experience with preparative chromatography.

Preferred Qualifications:

  • Five year professional/industrial GMP experience in a biotech, diagnostic, therapeutic or pharma company preferred.
  • Process/assay development experience will be useful for data interpretation, presentation and suggesting/implementing controlled improvements.


  • Excellent documentation and communication skills.
  • Ability to work independently as well as work as part of a cross functional team.
  • Comfortable with presenting and speaking in a variety of settings and with coworkers at a variety of levels.
  • Outcome-oriented and attentive to details with strong analytical and communication skills.

Why join Moderna Therapeutics:

Moderna Therapeutics is pioneering messenger RNA therapeutics™, an entirely new in vivo drug modality that produces human proteins or antibodies inside patient cells, which are in turn active intracellularly or secreted. This breakthrough platform addresses currently undruggable targets and offers a superior alternative to existing drug modalities for a wide range of disease conditions. Moderna has developed a broad intellectual property estate including 200 patent applications with 10,000 claims ranging from novel nucleotide chemistries to specific drug compositions. The company plans to develop and commercialize its innovative mRNA drugs—initially for rare diseases and oncology—while partnering drug candidates in other therapeutic areas in order to rapidly deliver this innovation to patients.

Based in Cambridge, Massachusetts, Moderna is privately held and was founded in 2010 by Flagship VentureLabs in association with leading scientists from Harvard University and Massachusetts Institute of Technology.

Moderna recently signed a collaboration agreement with Astra Zeneca that provided a $240MM upfront payment (plus milestone payments).

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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