Principal Scientist: Antibody Screening Specialist – Hybridoma

Pfizer (Global Research & Development) PGRD


February 19, 2014

Org Marketing Statement

All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That's why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place.

Role Description
We are seeking an experienced research scientist to implement antibody/immune protein generation strategies using state of the art hybridoma and B cell screening methods to deliver clinical candidates, and hit-to-lead equity for Pfizer research programs. The successful candidate will be responsible for generation of therapeutic antibodies using immunized approaches and will be expected to carry out high throughput screening and characterization of antibody hits. The candidate will work with cross-discipline project teams to deliver equity within defined timelines. The candidate may co-lead project teams during the early discovery/pre-clinical phases.

The position requires in-depth experience implementing antibody generation strategies using state-of-the-art hybridoma and B cell screening techniques. This includes design of immunization campaigns in wild-type and transgenic rodents, execution of hybridoma fusion, as well as single B cell sorting and culture. In addition, a proven track record of high throughput antibody screening using ELISA, FACS, cell-based assays is required. Strong skills in molecular biology and biochemistry and knowledge of antibody engineering is preferred.

Ph.D. in Cell Biology/Immunology or a related discipline with 5 to 7+ years of experience post PhD in a Pharmaceutical or Biotech setting leading scientific projects, in depth understanding in immune protein generation and characterization, excellent communication and leadership skills and the ability to work in multidisciplinary, team-oriented environment.

* Significant experience with antibody generation using state-of-the-art hybridoma and B cell screening techniques, including design of immunization campaigns in wild-type and transgenic rodents, hybridoma fusions, and B cell sorting and culture.
* Signficant experience in protein-protein and cell surface binding assays and cell-based activity assays used in the characterization and selection of immune binding proteins.
* Demonstrated experience in discovery and development of antibody based biotherapeutics from discovery to lead-optimization
* Familiarity with antibody/immune protein optimization and engineering technologies
* Familiarity with molecular cloning technologies, protein expression systems, and protein purification is a plus

Equal Employment Opportunity

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site.

Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.

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