Associate Scientist/Senior Associate Scientist, Cellular Process Development

bluebird bio

Scientist

May 12, 2014

Associate Scientist/Senior Associate Scientist, Cellular Process Development  

Stem cell and T cell therapies

 

bluebird bio is developing potentially transformative, one-time gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio’s product creation efforts is its broadly applicable gene therapy platform for the development of new treatments for diseases with few or no clinical options. bluebird bio has two clinical stage product candidates in development, one for childhood cerebral adrenoleukodystrophy (CCALD) and one for beta-thalassemia major/sickle cell disease, and an early stage oncology program in partnership with Celgene Corporation.

 

Join bluebird bio’s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach.  The focus of this position is to provide support for the development, qualification and characterization of the stem cell transduction and manufacturing process including the establishment of critical process parameters and controls for manufacturing. We are looking for an innovative scientist with the breadth of experience and drive to implement our vision for this function.

Activities include:

  • Use flow cytometry and other immunological assays to characterize human primary cells freshly isolated and following ex vivo culture
  • Assist in designing and testing  large scale, closed system manufacturing procedures for therapeutic  cell and/or gene therapy products from whole blood, apheresis, or bone marrow
  • Assist in designing and testing methods for the large scale isolation and  enrichment  of primary cells for therapeutic purposes  
  • Responsible for drafting process development SOP’s and reports
  • Exercise independent judgment in development of new methods, techniques and evaluation criteria 

Preferred Qualifications:

  • BS/MS cell biology, immunology or related discipline with 3-5+ years' experience in a relevant field
  • Have experience with FACS staining  and operating various types of flow cytometers 
  • Well versed in a variety of cell based methods with a strong understanding of tissue culture, cell biology, immunoassays, and general laboratory techniques.
  • Must be willing to have a flexible schedule based on experimental and company needs (including weekend work)
  • Ability to work in a team environment, meet deadlines, and prioritize and balance work from multiple individuals 
  • Strong verbal and written skills; ability to provide focus and clarity; able to handle confidential information and material appropriately
  • Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view
  • Independently motivated, detail oriented and good problem solving ability
  • Excellent organizational skills, sufficient to multi-task in a fast-paced environment with changing priorities
  • Experience with separation techniques using the Miltenyi AutoMACS and CliniMACS automated systems is desirable
  • Experience using the BD FACSAria or other cell sorters is highly favorable
  • Willingness to work with lentiviral vector and human biological samples (viral vector biology experience a plus)
  • Working knowledge of various computer software, hardware, and standard office sufficient to record scientific data and results, and prepare reports.
  • Be ready to embrace the principles of the bluebird bio culture:  b      colorful, b cooperative, and b yourself

 

This is an exciting time to join the field of gene therapy in general, and to become a part of the bluebird bio team in particular.  bluebird bio is a publicly traded company on the NASDAQ  Global Select Market and trades under the symbol BLUE.  We were recently named to the 2012 FierceBiotech Fierce 15. We offer a fast-paced, dynamic, collaborative, colorful, and scientifically rigorous environment, with all the fun and passion that a start-up provides, plus an excellent benefits package that includes stock options, commuter/parking benefit, etc.

To be considered for this exciting career opportunity, please apply through our website. www.bluebirdbio.com

bluebird bio, 150 Second Street, Cambridge, MA 02141

 bluebird bio will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. bluebird bio is not responsible for any fees related to resumes that are unsolicited.

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