STATISTICIAN-BIOINFORMATICIAN

Proteostasis Therapeutics, Inc.

Biostatistics

July 21, 2014

STATISTICIAN-BIOINFORMATICIAN 

POSITION SUMMARY

We are seeking a highly motivated statistician-bioinformatician for a key role at Proteostasis Therapeutics, Inc., driving the generation of hypotheses, design of experiments and statistical analysis across multiple projects in an interdisciplinary environment. 

Key RESPONSIBILITIES

  • Work closely with biologists towards the formation of hypotheses and the design and analysis of experiments to test said hypotheses
  • Discover and update causal hypotheses in transcriptomic, proteomic and other biological data
  • Perform meta-analyses on data from replicated experiments
  • Work with computational chemist toward developing predictive statistical models between chemical structures and biologic, transcriptomic and proteomic data
  • Work consistently with developer to pipeline key processes and capture data and analytic results. 

FUNCTIONAL KNOWLEDGE REQUIRED

  • Ph.D. with experience in statistics, physics and bioinformatics; industry experience a plus
  • Strong understanding of Design of Experiments theory, Bayesian statistical theory, computational Bayesian methods, hierarchical modeling, meta-analysis and Bayesian causal networks
  • Fluency in R, Matlab, BUGS, JAGS
  • Experience in working on complex problems and datasets containing biological noise, requiring creative hypothesis generation and careful analysis

 KEY SUCCESS FACTORS FOR the ROLE

  • Diverse applied knowledge of mathematical techniques for solving design problems
  • Excellent communicator with biologists; able to explain difficult statistical concepts intuitively
  • Creative and able to ‘think outside the box’
  • Capable of defending scientific choices
  • Highly motivated and proactive
  • Consistency in high-quality work
  • Team player capable of constructive collaboration within team and across departments
  • Awareness of current developments in applied Bayesian and bioinformatics literature
  • Ability to write and publish own work in scientific journals
  • Excellent presentation skills with a wide audience of diverse scientific expertise 

ABOUT PROTEOSTASIS

  • Proteostasis Therapeutics is backed by a consortium of leading venture capital firms, and has lead programs in cystic fibrosis and neurodegenerative diseases. The Company has made recent significant advances on both the science and business fronts.

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