Research Scientist II - Oncology - Biomarkers

Gilead Sciences

Research

July 31, 2014

Specific Responsibilities:

The Research Scientist II, Oncology Biomarkers will facilitate the development and execution of the biomarker and diagnostic strategy for research projects moving into development. He/she will work with Research Project Teams to design biomarker strategies, implement preclinical biomarker studies and oversee research biomarker testing and data analysis. The Research Scientist will be accountable for a portion of or the entire biomarker strategy, oversee technical aspects of biomarker assays and advise Research Project Teams on next steps. He/she will also evaluate the clinical applicability, validation status and any scientific, technical or statistical issues related to biomarker assay implementation. The Research Scientist will be a point of contact providing help and expert scientific advice related to biomarker sample collection, storage and sample and data analysis to Biomarker leads for implementation into clinical studies.

Essential Duties and Job Functions:

-Responsible for designing portions of or entire biomarker strategy for multiple Research projects in collaboration with Research team members.
-Advises teams on strategy for pharmacodynamics, predictive, disease monitoring, prognostic and other biomarkers
-Select relevant biomarker tests and oversee testing by Research teams by providing technical and tactical input
-Assist project teams with biomarker strategy and data analysis related to disease indication selection and in preclinical animal models
-Manages the development and validation of clinically applicable biomarker assays and may seek external service laboratories for specialized assay development
-Collaborates with biostatistics and bioinformatics for data analysis
-Participate hands-on in the lab when necessary to facilitate and assist with biomarker assay development, testing and/or validation
-Oversight of one or more research associates may be required
-Collaborates with Biomarker Lead Scientists and Clinical Operations by providing biomarker requirements to Clinical Operations for sample collection, handling and analysis for clinical studies
-Reviews and contributes to biomarker sections of clinical protocols, lab manuals, and clinical study reports as needed

Knowledge, Experience and Skills:

-PhD in Cancer Biology, Cell Biology, or Molecular Biology or related field and a minimum of 5 years research experience in a pharmaceutical or biotech environment. Must have biomarker expertise in one or more of the following therapeutic areas: oncology, hematology, immunology, or inflammation
-Experience with the discovery, characterization, clinical validation and utilization of innovative biomarkers and potential diagnostics
-Direct laboratory experience with biomarker identification, selection and testing in cell lines and/or primary samples including whole blood and tissue
-Experience with ELISA, MSD, flow cytometry, RNAseq, NGS, qPCR, and protein arrays
-Experience in development, outsourcing and validation of clinically applicable biomarker assays is desirable
-Excellent verbal communication and interpersonal skills are required
-Must be able to multi-task, manage multiple projects simultaneously and work effectively within a team environment
-Managerial experience a plus
-Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment

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