Research Associate II/III

Broad Institute of MIT & Harvard


August 1, 2014

This position is a unique opportunity to join the laboratory of Eric Lander, Founder and Director of the Broad Institute of MIT and Harvard, to study genome biology. With the sequencing of the human genome, we discovered that protein-coding genes comprise only 2% of our genome sequence and that much of the critical regulatory information resides in the remaining 98%. Recently, our group described a new class of genes (lincRNAs) that do not encode proteins.

These noncoding RNAs play critical roles in genome regulation during development and disease, but their exact functions and mechanisms remain unknown. We are looking for a highly motivated individual with significant experience in experimental biology to join our team working to characterize these noncoding RNAs. The successful candidate will help to decipher the genetic code controlling lincRNA function by applying high-throughput techniques in biochemistry, molecular biology, cell biology, and cell imaging. This project will include systematic purification of lincRNA complexes and application of next-generation DNA- and RNA-sequencing technologies to define the regulatory interactions of lincRNAs in embryonic stem cells.

This project will also include the development and refinement of novel molecular biology techniques. The successful candidate will have the opportunity to contribute to all levels of the scientific process, including designing, performing, and interpreting experiments as well as writing and presenting results.The Lander Laboratory is a dynamic, interdisciplinary workplace that will provide unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of resulting scientific contributions.

- Works with team members to develop, design, and carry out experiments that are essential to the group’s collective success
- Interprets experimental results; documents, summarizes and presents findings in individual and group meetings
- Consults with other staff, senior scientists, or primary literature to learn or develop new experimental protocols
- Consults with team leader on priorities, methods, and timelines- Maintains a detailed organizational plan and record to ensure successful and timely completion of required tasks
- Other tasks as required
- Bachelor’s or Master’s degree in Biology or related field. Highly motivated candidates of all levels are encouraged to apply.
- 2+ years of experience in a research laboratory, preferably in an independent project.
- Strong technical knowledge and experience with basic molecular biology techniques such as PCR, gel electrophoresis, and nucleic acid purification.
- High level of initiative and motivation; ability to work independently and with a team
- Excellent communication, organization, and time management skills
- Ability to think creatively to solve problems
- Experience with mammalian cell culture, RNA or protein biochemistry, and/or mammalian genetics preferredThe Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

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