Research Associate II

Broad Institute of MIT & Harvard


August 1, 2014

The aim of the Stanley Center for Psychiatric Research is to reveal the genetic, molecular, cellular and circuitry underpinnings of psychiatric disorders. Within the last year, the Stanley Center and the psychiatric genetics community have been very successful unprecedented insights on the genetic causes of these debilitating disorders. Now, the difficulty lies in how to translate the genetic findings into neurobiological mechanisms, which is essential for the identification of drug targets and eventually the development of effective treatments.

Perform bench level experiments as well as computational analysis to assist with projects to support the overall research goals of the Chemical Neurobiology Laboratory of the Stanley Center for Psychiatric Research at the Broad Institute. Work as a key member of a dynamic multi-disciplinary effort to discover novel diagnostics or therapeutics for schizophrenia and bipolar disorder, using varied approaches including genetics, chemical biology and neurobiology. The position requires proficiency in a broad repertoire of molecular and cellular techniques and computational skills. Communicate effectively with all levels of staff to ensure that work supports current team goals.

The individual will work under guidance of one of our project leaders. Research will be conducted from experimental design and execution through data analysis. May require problem solving, such as identifying technical problems, revising protocols, and investigating alternative methods. The individual will interact and collaborate closely with other scientists and will be involved in a series of research activities, including experimental design, collaborative efforts between research groups, and the verbal and written communication of science. This is a 6 months contract position.

Key Responsibilities:
- Perform biochemical assays including westerns to address MOA in GSK3b projects - 30%
- Perform biochemical analysis including EILIZA (GSK3 project) - 30%
- Dissecting the signaling of Barr2 and Barr1 KO cells to support D2R project - 40%
- BS 2+ years experience or MS in biology required. (MS in biology or neurobiology preferred)
- Experienced with mammalian cell culture Desirable with culturing primary neurons
- Experienced with biochemical analysis using western blots and ELISA
- Experience with basic molecular biology (e.g. cloning, DNA/RNA isolation, PCR)
- Good organizational skills and excellent attention to detail
- Excellent documentation skills
- Must have good interpersonal skills
- Computer experience (e.g. Excel, PRISM)
- Ensures quality control of equipment, reagents
- Ordering and inventory of laboratory supplies
- Verbal and written communication of experimental results

The Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

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