Principal Scientist / Group Leader, ImmunoPharmacology

EMD Serono, Inc.

Pharmacology

August 18, 2014

Job Title: Principal Scientist / Group Leader, ImmunoPharmacology

Req# 44964

 

EMD Serono is the biopharmaceutical division of Merck KGaA, Darmstadt, Germany, a global pharmaceutical and chemical group. We strive to create value and benefit patients by transforming medical science into breakthrough solutions in our core therapeutic areas of neurodegenerative diseases, fertility and metabolic endocrinology, as well as oncology and autoimmune/inflammatory diseases as emerging areas of expertise.

PURPOSE OF THE ROLE

The candidate provides scientific leadership and expertise to a small group of direct reports on multiple projects. The incumbent will be responsible for in vivo immunopharmacology studies for novel cancer immunotherapy concepts including cancer vaccines, tumor inflammation and immune tolerance. Study results will be translated into clinically relevant biomarkers. The candidate will effectively lead discovery project teams in cross-functional activities and executes against projected timelines and budget. He/she demonstrates scientific leadership in the field of cancer immunotherapy, is recognized as a leader in his/her area of expertise and translational research. The person actively enriches the cancer immunotherapy pipeline through championing internal projects and support of collaborations with external partners.

KEY TASKS & RESPONSIBILITIES

  • Contribute to the implementation of the ImmunoOncology research strategy
  • Drive early drug discovery projects in ImmunoOncology by designing, conducting and overseeing in vivo pharmacology studies in murine tumor models
  • Apply understanding of PK/PD to studies designed to define the appropriate dose & schedule for novel biological and small molecule agents
  • Keep abrest with cutting-edge in vivo models that can be applied to concept discovery and durg candidate characterization in the field of cancer immunotherapy
  • Lead and manage a small research group of scientist or temporary staff, including hiring and training as necessary
  • Focus on immune readouts (i.e., FACS-based immunophenotyping, T cell activation assays) that can be incorporated into an early clinical development setting
  • Represent ImmunoOncology as a member of multi-disciplinary Discovery Project Teams; may serve as a Discovery Project Team Leader responsible for ensuring the execution of drug discovery projects according to set timelines
  • May represent ImmunoOncology as a member of global development project teams
  • Serve as a point of contact and collaborator with external academic and corporate partners
  • Provide input on all IND/NDA/BLA preparation activities including data collection, analysis and write-up of biomarker and pharmacodynamic endpoints.
  • Participate in authorship of scientific and/or patent publications.
  • Facilitate productive interactions with other functions outside of ImmunoOncology and stimulate cross-functional ideas for immunotherapeutic approaches
  • Follow and promote safety instructions and regulations according to Quality Management Standards.
  • Provide mentorship and career development support for direct reports or temps

 

 

EDUCATION/LANGUAGES

  • A Ph.D (and/or M.D.) in biological sciences
  • Fluency in written and spoken English required

 

PROFESSIONAL SKILLS & EXPERIENCE

  • Ph.D. and 7 to 11 years of post doc related experience or MS and 13 or more years experience or BS and 15 years experience
  • Track record of scientific excellence and successful advancement of new therapeutic principles in industry or academia
  • Must have detailed knowledge of in vivo pharmacology in the field of oncology; knowledge of, and experience in developing cancer immunotherapeutics is highly desired
  • Comprehensive understanding of in vivo models utilized in oncology a must; experience with the use of syngeneic or humanized models to study immunotherapies is highly desirable
  • Understanding of immunological readouts and their translation into early clinical trials is a major plus
  • Capability to manage teams with previous demonstrated ability to work as an effective leader across different functional groups
  • Experience with managing academic research collaborations
  • Solid publication record
  • Background in immunology, and specifically cancer immunology, is highly desired

 

PERSONAL SKILLS & COMPETENCIES

  • Very good oral and written communication skills
  • Demonstrated ability to write scientific reports and publications
  • Excellent presentation skills
  • Team player with strong interpersonal and leadership skills
  • Well-organized and self-directed; able to adhere to tight timelines
  • Forward-thinking and creative with high ethical standards

 

Equal Employment Opportunity

The Company is an Equal Employment Opportunity employer.

No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, or any other classification protected by applicable federal, state, or local law.

This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment.

Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to his/her Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because he/she made a good faith report of discrimination

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