Using the QTcI in Clinical Trials

Tuesday, January 29 2013
11:00 am – 12:00 pm

Title: Using the QTcI in Clinical Trials

Live Webcast: January 29, 2013 11:00 AM - 12:00 AM EST

To compensate for the heart rate effects on the QT-interval, a so-called “correction factor” is used. While there are many to choose from, regulatory agencies tend to favor the Fridericia’s correction (QTcF). In some instances, the QTcF is not appropriate. When this happens, an individual correction formula (QTcI) can be calculated. In this Webinar, we will discuss the use of correction formulae, including the purpose and use of different correction formulae.

Learning Objectives:

  • What are QT correction formulae
  • How to choose a correction formula
  • What is the QTcI
  • Calculation methods for the QTcI
  • Validation QT correction methods

Speaker:

Dr. Timothy Callahan
Chief Scientific Officer
Biomedical Systems

Dr. Timothy Callahan received his Ph.D. from Capella University in Interdisciplinary Studies with a concentration in Research Methodology. He has conducted research in Silent Myocardial Ischemia at the National Institutes of Health in Bethesda Maryland. Dr. Callahan has been in the research industry for over 20 years. An expert in diagnostic testing, he co-authored 2 patents in QT interval analysis and has authored many abstracts and publications. Dr. Callahan has moderated the past three ECG core lab roundtable meeting with Dr. Norman Stockbridge and QTIRT of the FDA. He is a frequent speaker at Pharmaceutical Industry functions, including acting as the co-chair of the October, 2002 DIA "ECGs in Clinical Trials" meeting.

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