Downstream Processing - MIT Short Course

Monday, August 5 – Friday, August 9 2013

This event was posted by Massachusetts Institute of Technology

Location: MIT Campus | Cambridge, MA

Continuing discoveries in molecular biology, genetics, and process science provide the foundation for new and improved processes and products in today's biochemical process industry. The production of therapeutic proteins, which is made possible by discoveries in biotechnology, will generate sales exceeding $100 billion in 2010. In addition, biotechnology has led to marked improvement and expansion in the traditional biochemical process industry for production of enzymes, diagnostics, chemicals, pharmaceuticals, and foods. Continued introduction of new technology necessitates innovation in process development scale-up and design. As a consequence, there is the need to design new, as well as to improve existing, processes. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification.


The course covers fundamental principles of downstream processing with practical examples and case studies to illustrate the problems and solutions faced by the practitioner. It is intended to provide both insight into and an overview of downstream processing for individuals actively engaged in process research and development, as well as those who manage and innovate in the biochemical process industry. Increasingly, scientists and engineers engaged in fermentation and cell culture development attend the course to better understand the context of the whole process. Attendees include:

  • Engineers and scientists interested in design, economics, validation optimization and scale-up of biochemical product recovery;
  • Protein biochemists and chemists involved in design of recovery processes;
  • Managers responsible for biochemical process development;
  • Entrepreneurs, attorneys, and business leaders wanting an overview and insight into biochemical manufacturing.


The program is under the direction of Professor Charles L. Cooney. Lectures will be presented by:

Dr. Stuart E. Builder, Strategic Biodevelopment, Belmont, CA

Dr. Charles L. Cooney, Professor of Chemical and Biochemical Engineering at MIT

Dr. Brian D. Kelley, Vice President - BioProcess Development, Genentech, South San Francisco, CA

Dr. Daniel I.C. Wang, Institute Professor of Chemical Engineering, Department of Chemical Engineering at MIT

Dr. Inger Mollerup, Vice President, Novo Nordisk, Denmark

Mr. Jean-Francois Hamel, MIT, runs the teams projects


Learn more about all MIT Professional Education Short Programs

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