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Ensemble Discovery Corporation

Category: Research Products and Instrumentation
Phone: 617-492-6977
Fax: 617-492-6689
Website: http://www.ensemblediscovery.com

Ensemble Discovery Corporation is developing a novel approach to chemical discovery based on a highly integrated set of processes that combine chemistry, biology and nanotechnology. Central to our approach is DNA Programmed Chemistry (DPC), an innovative method for chemical synthesis based on the groundbreaking work of Professor David Liu of Harvard University. DPC employs short complementary DNA strands with chemical moieties attached at each end to drive chemical reactions, creating new bonds and novel compounds. Libraries containing complex, diverse, pure and soluble drug-like small molecules can be generated in a single pot. A nanoscale affinity-based selection system is then used to identify binders with a wide dynamic range and to efficiently generate comprehensive, data-driven SAR. Ensemble is applying the technology to identify unprecedented chemical bond formations as well as to discover human therapeutics and detection products, including research tools, clini! cal diagnostics, and other specialty chemicals. The company has a broad intellectual property portfolio and has raised capital from a premier group of investors. Located in Cambridge, MA, Ensemble has assembled a world-class team of scientists and entrepreneurs and aims to generate new products that address significant unmet needs.

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