Membership Directory
Antigen Express, Inc.
Category: Drug Development
Phone: (508) 852-8783
Fax: (508) 852-8653
Website: http://www.antigenexpress.com/
Antigen Express, Inc. (AE) has discovered lead compounds which regulate the first step in the immune response. AE compounds enhance or inhibit presentation of antigenic peptides to T cells. The AE compounds are derivatives of a segment of the Ii immunoregulatory protein, which during its cleavage and release from MHC Class II molecules acts at an auxiliary regulatory site to control the insertion and locking in of antigenic peptides into the antigenic peptide binding through of the MHC class II molecules, for presentation to T cells.
Clinically useful control of this first step in the immune response would allow antigen specific therapy of many diseases, perhaps associated with the genetic alleles of MHC class II linked to disease, without the many toxic side effects of current immunosuppressive therapies.
PHONE: 617.674.5100
EMAIL: