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ArQule, Inc.

Category: Drug Development
Phone: 781-994-0300
Fax: 781-376-6019
Website: http://www.arqule.com

ArQule is a clinical-stage biotechnology company engaged in the research, development and commercialization of targeted cancer therapeutics. Our expertise in molecular biology enables us to understand certain biological processes that are responsible for human cancers and to discover novel drug candidates for these diseases. Our chemistry capabilities, derived from our history of providing chemistry services for the pharmaceutical and biotechnology industries, enable us to generate product candidates possessing certain pre-selected drug-like properties and a high degree of specificity for cancer cells. We believe that these qualities, when present from the earliest stages of product development, increase the likelihood of producing safe, effective and marketable drugs. Our lead products are in clinical-stage development. We are conducting human clinical trials with three product candidates, designated as: ARQ 197, ARQ 501 and ARQ 171. We retain proprietary rights to ARQ 197 and are developing ARQ 501 and ARQ 171 pursuant to a collaboration with Hoffmann-La Roche. ARQ 197 is the lead product from our Cancer Survival Pathways Program. ARQ 197 blocks the activity of c-Met, an enzyme believed to play key roles in human cancer, including cancer cell growth, survival, angiogenesis, invasion and metastasis. We believe the inappropriate expression of c-Met in most cancers and its role in controlling multiple signal transduction pathways involved in tumor growth and metastasis render it a highly compelling target for cancer therapy. ARQ 501 and ARQ 171, the lead products from our Activated Checkpoint Therapy® program, are designed to kill cancer cells selectively while sparing normal cells through direct activation of DNA damage response/checkpoint pathways. These compounds are believed to activate checkpoint pathways regulated by the E2F-1 regulatory protein thereby restoring the cell’s natural defense mechanism against DNA damage and initiating the process of apoptosis in these cells.

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