pION Biopharma Services Announces Caco-2 Permeability Measurement

January 12, 2010

Caco-2 permeability measurement builds upon the expertise of pION in drug adsorption measurement and SBH Sciences, Inc. in cell-based assays.  This ensures that pION Biopharma Services can accurately measure Caco-2 permeability when other labs may fall short.

Permeability is critical to drug bioavailability, which lies at the heart of the Biopharmaceutical Classification System endorsed by the FDA.  This new offering from pION Biopharma Services complements their already comprehensive test methods which includes dissolution, solubility, Double-SinkTM PAMPA and ionization.  The Caco-2 measurements employ cell cultures which feature active transporters that can also affect the availability of some drugs.

"Highly permeable compounds are also amongst the least soluble and we take that into account when we design a Caco-2 experiment," said Alex Avdeef, CEO/CSO and co-founder of pION. "Some customers have enlisted our services after Caco-2 measurement elsewhere failed to obtain a detectable, measureable amount.  Since that result was not consistent with the accumulated data on their API, we took the extra time and effort to design a more meaningful experiment.  The customer was delighted that the result was in accordance with previous data."

"We're excited to be working with pION", said Raphael Nir, President of SBH Sciences.  "With our demonstrated ability in developing cell-based bioassays and efficient cell culture processes, we're in a unique position to deliver consistent Caco-2 cultures on a regular basis.  We do this every day."

With pION Biopharma Services, Caco-2 permeability is determined under a variety of conditions, including apical to basilateral, basilateral to apical, iso or gradient pH, and with UV or LC/MS detection.  Depending on selected conditions, reports may include permeability and efflux ratios. 

 

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