Hyaluron Contract Manufacturing (HCM) Announces Patent Approval

June 24, 2008

BURLINGTON, Massachusetts June 24, 2008 - Hyaluron, Inc. dba Hyaluron Contract Manufacturing (HCM) is pleased to announce the grant of a patent and the registration of a trademark for its proprietary process for aseptic online vacuum filling and online vacuum stoppering of low viscosity liquids in syringes. BUBBLE-FREE FILLING® enhances product stability for oxygen sensitive compounds where dissolved oxygen negatively impacts solution stability. BUBBLE-FREE FILLING® also provides additional assurances of sterility by reducing stopper movement as well as creating an unfavorable environment for the growth of aerobic micro-organisms.

HCM was able to develop the BUBBLE-FREE FILLING® method by re-engineering standard syringe filling equipment and creating a unique fluid handling and transfer process. HCM has another patent pending for a proprietary aseptic processing method for non-destructive testing of container/closure integrity. HCM is continually striving to improve the safety and effectiveness of drug delivery through its innovative processes.

About Hyaluron Contract Manufacturing

Hyaluron Contract Manufacturing aseptically fills liquid and lyophilized products into syringes, vials, and custom containers. In addition to traditional formulations, HCM excels in process development scale up of difficult formulations including: emulsions; viscous gels; suspensions, liposomes, and proteins. For additional information please visit: www.hyaluron.com and www.bubblefreefilling.com.

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