July 12, 2011

Pittsfield – Worcester, MA – Nuclea Biotechnologies Inc. and Clark University today announced an expansion of their research partnership and the establishment of a new Proteomic and Metabolomic Center on the Clark University Campus.  The center will offer high performance bioinformatics cluster resources that will allow Nuclea and Clark to analyze, identify, and quantify targets at the molecular level – a critical component to modern biomedical research, clinical diagnostic discovery, and drug development efforts.


To further the scientific goal of Nuclea and Clark, the center brings together state-of-the-art sample preparation equipment, advanced mass spectrometry instrument (GC/MS and LC/MS), along with the established NMR facility at Clark.  Furthermore, the enormous amount of data generating from the clinical repository at Nuclea or scientific samples from Clark will be analyzed through the newly established computer cluster network at Clark and the proprietary database of Nuclea.  This collaboration will serve as a model in the development of academic/industrial partnership that will benefit the biotech community and higher learning institutes. 


“We are extremely excited about this new partnership,” said Patrick J. Muraca, president & CEO of Nuclea and an alumnus of Clark.  “The research being conducted at Clark, using the state-of-the-art equipment and technology, will lead to new biomarkers that will help doctors identify deadly cancers in hard-to-diagnose patients and proscribe the most effective treatments.”


Nuclea discovers and develops biomarkers (genes, proteins, and antibodies) and diagnostic assays that can help predict which treatments will be effective for certain patients, depending on their genetic makeup.  Proteins or metabolites are complex molecules that are produced in every cell of the body.  They regulate biologic functions, give structure to cellular components and send signals within and between cells. There are thousands of active proteins or metabolites in every cell, many of which remain poorly understood.  Hence, some of them will be unique biomarkers of disease, drug target and new mechanism of biology.  Researchers at Clark University and collaborators at Nuclea can now study which targets or pathway is over-expressed or altered in a cancer cell. 


“High dimensional biological and clinical understanding of the proteins or metabolites can now be measured at the level of their expression and modifications.  This is only recently achievable with the advanced mass spectrometry instrumentation and software development for high performance database search of proteins and metabolites,” said Sunny Tam PhD, VP of R&D at Nuclea and Research Associate Professor of Clark University. 


“The combined facility will also continue to serve the Clark university faculty and student researchers so that it will further strengthen the research activities on campus,” said Fred Greenaway PhD, Chairman of Chemistry and Biochemistry of Clark University.



Nuclea Biotechnologies, INC -- is headquartered in Pittsfield, Massachusetts with additional operations in Worcester, Massachusetts. Nuclea has developed and is commercializing eleven unique diagnostic tests for colon, breast, leukemia, lung and prostate cancer. Nuclea also performs research leading to novel molecular oncology therapeutics and diagnostics for the pharmaceutical and biotechnology industries.


Clark University – Since its founding in 1887, Clark University in Worcester, Mass., has a history of challenging convention. As an innovative liberal arts college and research university, Clark’s world-class faculty lead a community of creative thinkers and passionate doers and offer a range of expertise, particularly in the areas of psychology, geography, urban education, Holocaust and genocide studies, environmental studies, and international development and social change. Clark’s students, faculty and alumni embody the Clark motto: Challenge convention. Change our world.


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