February 13, 2013

Harlan Laboratories Contract Research Services has expanded its capabilities in General Toxicology and Inhalation to support the chemicals, agrochemicals and pharmaceutical sectors with the arrival of Brian Anderson as Manager of Safety Assessment, Harlan Laboratories Switzerland.

This latest senior appointment further strengthens Harlan’s service offering across its specialist divisions and, supported by ongoing investment in new equipment and continued enhancement of procedures, underlines the company’s commitment to providing the highest levels of expertise and support to its expanding client base.

Brian has worked as a senior toxicologist and Study Director in the CRO industry for over 28 years, with particular specialisation in inhalation, and brings with him a successful track record in managing GLP toxicology teams.  Prior to Harlan CRS, he was a Study Director at Life Science Research and undertook a number of senior roles at CRL, Edinburgh. 

As well as his involvement in a large number of inhalation and intranasal studies, including all aspects of aerosol science, Brian has been a major contributor to the development of rodent, dog and primate inhalation facilities.  In addition, he has provided scientific expertise for cross-discipline projects such as reprotoxicology via the inhaled route and has developed particular expertise in inhalation exposure for neonatal/juvenile investigations in dogs.  Brian has also contributed to several international document review panels for OECD.

Brian’s appointment adds to the already extensive expertise and in-depth knowledge across the Harlan inhalation teams, with skilled study directors and technicians offering a combined experience of over 300 years, which means that the company is ideally placed to bring an immediate impact to new studies.

This significant level of expertise has also enabled Harlan to take the initiative in the area of carbon nanotubes (CNT).  With the recent review of Donaldson et al (Particle and Fibre Toxicology 2010 7:5) highlighting that “the essentially fibrous structure of CNT has led to concern that they might cause asbestos-like pathology in the lung and mesothelium”, Harlan has become the first CRO to test CNTs to international standard guidelines (13 week inhalation studies according to OECD 413 and OPTS 870.3465) with additional end points.  Information relating to some of this work will be presented at this year’s SOT meeting in San Diego, USA.

Harlan is continuing to further enhance its service with the investment in state of the art equipment such as its new Wide Range Particle Spectrometer for CNT inhalation studies which enables the measurement of particles down to 5 nm.

In addition, as part of the consolidation of the company into a single site at Itingen and its commitment to improved service, Harlan is rebuilding and upgrading its Inhalation capacity during 2013 to provide modernised, purpose-designed facilities.





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