Epistem co-presents biomarker data at the ASCO 2013 Annual Meeting

May 28, 2013

MANCHESTER, UNITED KINGDOM -- (Marketwire-May 28th 2013) - Epistem Plc. (LSE: EHP), the UK biotechnology and personalised medicine company, today announced that it has co-authored a poster reporting biomarker data that will be presented at the American Society of Clinical Oncology Annual Meeting, ‘Building Bridges to Conquer Cancer’ in Chicago on 31st May to 4th June 2013.

The poster entitled ‘Exploration of a hair follicle gene signature as a potential pharmacodynamic marker for the dual PI3K/mTOR inhibitor VS-5584’ will be presented during the Tumor Biology Poster Session (Abstract # 11064).

Dr Gino Miele, Operations Director of Epistem’s Biomarker Division, is the co-author of the poster that reports data being presented on Epistem’s plucked hair biomarker platform. Epistem’s ex vivo plucked hair platform has successfully identified multiple clinical pharmacodynamic biomarkers resulting from pharmacologic inhibition of the PI3K/mTOR signalling pathway, a commonly dysregulated cancer pathway.

Plucked scalp hair represents a practical surrogate tissue for monitoring drug effects in patients. The gene signatures identified in this study may be used to provide further mechanism of action information in clinical settings and can be used to monitor pharmacodynamic responses from a non-invasive surrogate tissue obtained from cancer patients.

Matthew Walls, Chief Executive Officer of Epistem Ltd. commented: “This data supports our expertise in PI 3-Kinase pathway biomarker panels. Epistem are at the forefront of clinical biomarker research and this data further strengthens our position as the preferred partner of choice for pharmaceutical and biotechnology companies.”

For further information on the Company please visit www.epistem.co.uk or contact:

US Office - Lydia Meyer-Turkson +1 (0) 781 859 7937
UK Office - Benjamin Reed +44 (0) 7881 660 737
Epistem Plc. info@epistem.co.uk

Notes to Editors:

About Epistem

Epistem is a biotechnology and personalised medicine company commercialising its expertise in epithelial stem cells and pharmacogenomics in the areas of oncology, gastrointestinal, dermatological and infectious disease.

Epistem develops innovative therapeutics, biomarkers and diagnostics alongside providing preclinical services to drug development companies. Epistem’s core expertise is focused on the regulation of adult stem cells located in epithelial tissue which includes the gastrointestinal tract, skin, hair follicles, breast and prostate. Epistem also has a range of proprietary amplification (RNA and DNA) technologies for use in drug discovery, development and diagnostics. www.epistem.co.uk

BioFlash

Membership Deliverables

MassBio Membership gives you:

Purchasing power-MassBio negotiates a broad-based collection of services on behalf of member companies and passes the savings on to its members. 

Networking and professional development-MassBio organizes and executes numerous conferences, committee meetings, and networking events throughout the year.

MassBio Signature Events-Attend our Investors Forum, Innovator Roundtables, Pharma Days, our Golf Classic Fundraiser, Policy Leadership Breakfast, and many others.

Public policy & Advocacy-As the state's leading advocate for our life science super cluster, we fight for public policy initiatives and tax incentives in Massachusetts and Washington, D.C., that will enable biotechnology companies to do their best work.

Economic development-MassBio provides expert advice and guidance to help companies find suitable locations and resources as they move to and grow in the Bay State. We make Massachusetts a better place for your business.

Visibility/Resources-Members are listed on a searchable directory that includes a profile and link to the company's website. We highlight your company's latest news by posting to our MassBio member news page. In addition, members can post job openings on our website free!

Educational incentives-We promote education, workforce development and lifelong learning through the MassBioEd Foundation. The foundation customizes training programs for companies and educational institutions and promotes science in the classroom through BioTeach. MassBio members receive a discount on courses offered by the foundation.