RainDance Extends Sequence Enrichment Solution Capabilities With Methyl-Seq and Ultra-Deep Resequencing Applications

October 22, 2009


HONOLULU, HAWAII, U.S.A., October 22, 2009 - RainDance Technologies, Inc., a leading provider of innovative microdroplet-based solutions for human health and disease research, announced today it will extend the capabilities of its Sequence Enrichment Solution by offering Methyl-Seq and Ultra-Deep Resequencing applications.

In a presentation at the 59th Annual Meeting of the American Society of Human Genetics, the company said these enhancements represent a significant expansion of the RainDance technology platform's capabilities. They will enable researchers to use their RDT 1000 instruments for epigenomic and ultra-deep resequencing studies that can accurately characterize the molecular basis for cancer and other destructive diseases.

"Methyl-Seq and Ultra-Deep Resequencing will provide exciting new tools to our customers' research methodologies," said Christopher McNary, President and Chief Executive Officer, RainDance Technologies. "Now scientists can apply our Sequence Enrichment Solution to gain better understanding of how disease cells differ from normal cells, enhancing their understanding of the origins and pathways of complex diseases."

Methyl-Seq Allows Use of PCR-Based Enrichment and Next-Generation Sequencing for Higher-Resolution Epigenomic Studies

RainDance said its Methyl-Seq application will provide scientists with new capabilities for epigenomics research, a field recognized in a National Institutes of Health Roadmap as having exceptionally high potential to transform biomedical research.  The study of epigenomics explores how factors such as environment can change gene expression and gene activity over time in a manner that heightens susceptibility to disease. 

The Methyl-Seq application will allow researchers, for the first time, to combine PCR-based sequence enrichment with the power of next-generation sequencing platforms to perform epigenomic studies at significantly higher resolution. By studying methylation patterns with single-base resolution across targeted regions of the genome, researchers can get a better understanding of epigenomic variation and can discover opportunities to develop new treatments for cancer and other complex diseases.

"Methyl-Seq enables the targeted amplification and next-generation sequencing of bisulfite-converted DNA for the identification of methylated bases in the genome with greater accuracy and quality of data," said McNary.

Ultra-Deep Resequencing Enables PCR-Based Enrichment to Accurately Characterize Variance in Heterogeneous Samples

RainDance's Ultra-Deep Resequencing application enables the use of the company's PCR-based Sequence Enrichment Solution to accurately characterize rare variants in highly heterogeneous samples, such as those found in cancer tumors. Studies suggest that rare genetic variants may play significant roles in tumorigenesis, pathogenesis, and disease progression. Previously, ultra-deep resequencing of heterogeneous samples with standard PCR approaches has been difficult because of the loss of accurate DNA representation.

"The unique compartmentalization capability of our RainStorm microdroplet-based technology provides highly efficient amplification of all sequence variants in the sample," McNary said. "This ensures that accurate representation and a high depth of coverage are maintained for ultra-low frequency variants."

Both the Methyl-Seq and Ultra-Deep Resequencing applications will be commercially available during the first half of 2010. They will utilize the RDT 1000 system's proven consumables and reagents.

"The capabilities of these new applications, plus the expanded-content DNA primer libraries and WGA sample protocols announced last month, make the RDT 1000 a highly flexible genomic research platform that easily integrates with any next-generation sequencing workflow," said McNary. "Both the Methyl-Seq and Ultra-Deep Resequencing applications are simple to use and integrate seamlessly with our Sequence Enrichment Solution. Our applications will help researchers rethink their approaches to discovery as they unlock the cures for the world's most devastating diseases," he said.


About RainDance Technologies, Inc.

RainDance Technologies, Inc., is a provider of innovative microdroplet-based solutions for single-cell analyses that will accelerate human health and disease research. The speed and simplicity of the company's exciting new technology platform enable researchers to design experiments in ways that were previously unaffordable or unimaginable. The company's RainStormTM technology produces picoliter-volume droplets at a rate of 10 million per hour. Each droplet is the functional equivalent of an individual test tube and can contain a single molecule, reaction, or cell. This versatile technology can adapt proven assays for high-speed workflows with minimized process-induced bias or error.

RainDance's initial application focuses on the targeted sequencing of the human genome - one of the fastest-growing segments of the $1 billion DNA sequencing market. This application enables the high-resolution analysis of genetic variation between individuals and populations at a level unmatched by current methodology.

For more information, please visit www.raindancetech.com.

RainStorm is a trademark of RainDance Technologies, Inc.



Membership Deliverables

MassBio Membership gives you:

Purchasing power-MassBio negotiates a broad-based collection of services on behalf of member companies and passes the savings on to its members. 

Networking and professional development-MassBio organizes and executes numerous conferences, committee meetings, and networking events throughout the year.

MassBio Signature Events-Attend our Investors Forum, Innovator Roundtables, Pharma Days, our Golf Classic Fundraiser, Policy Leadership Breakfast, and many others.

Public policy & Advocacy-As the state's leading advocate for our life science super cluster, we fight for public policy initiatives and tax incentives in Massachusetts and Washington, D.C., that will enable biotechnology companies to do their best work.

Economic development-MassBio provides expert advice and guidance to help companies find suitable locations and resources as they move to and grow in the Bay State. We make Massachusetts a better place for your business.

Visibility/Resources-Members are listed on a searchable directory that includes a profile and link to the company's website. We highlight your company's latest news by posting to our MassBio member news page. In addition, members can post job openings on our website free!

Educational incentives-We promote education, workforce development and lifelong learning through the MassBioEd Foundation. The foundation customizes training programs for companies and educational institutions and promotes science in the classroom through BioTeach. MassBio members receive a discount on courses offered by the foundation.