Knowledge Base

3D Primary Human Hepatocytes (PHH) Spheroids Demonstrate Increased Sensitivity to Drug-induced Liver Injury in Comparison to 2D PHH Monolayer Culture February 5, 2019

In the present study, a 100-compound screen was performed (using DILI and control compounds selected based on recent publications7,8) to examine the response of 2D monolayer vs. Read More

Leading Courageously in Healthcare XBInsight February 3, 2019

Workforce Development

Download our latest research paper "Leading Courageously In an Evolving Healthcare Environment". Read More

Fortune 500 Pharmaceutical Company Case Study XBInsight January 9, 2019

High turnover in a key scientist role was plaguing this Fortune 500 multinational pharmaceutical company, greatly hindering productivity and advancements in this critical function. Read More

First-line Lung Cancer: Can Keytruda Be Stopped? EvaluatePharma USA, Inc. November 30, 2018 in White Papers,

Innovation,
Value

The year that started with the promise of a first-line lung cancer shakeout looks likely to end with Merck & Co’s Keytruda, the drug that started in pole position, even more entrenched than before. Read More

Security of supply for chromatography media GE Healthcare Life Sciences November 30, 2018 in White Papers,

Biomanufacturing

Reliable, long-term supply of key manufacturing components is essential over the lifetime of a biologic. A security of supply program can help maintain manufacturing of vital biopharmaceuticals. Read More

Single-use technology and sustainability: quantifying the environmental impact in biologic manufacturing GE Healthcare Life Sciences November 30, 2018 in White Papers,

Single-use technologies offer productivity & flexibility benefits to biopharma manufacturers. This WP Life Cycle Assessment (LCA) considers the value chain & multiple environmental impact categories. Read More

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates November 7, 2018 in Research Papers,

Innovation

Our results demonstrate that not all tumour-infiltrating T cells are specific for tumour antigens... measuring CD39 expression could be a straightforward way to quantify or isolate bystander T cells. Read More

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells November 7, 2018 in Research Papers,

Innovation

Our results provide insights into the nature of neoantigen-specific T cells and the effects of checkpoint blockade immunotherapy. Read More

Exercising Your ISOs in the New Tax Environment Freedom Trail Financial September 28, 2018 in White Papers,

Workforce Development

Biotechnology and pharma stocks had a great run this summer, so now may be a good time to look at your incentive stock options (ISOs) and how recent changes in the calculation of the Alternative Minim Read More

Maximize Your Convention Marketing Results: Development of Strategies for Biotechs from Pre-Launch Through Product Maturity Poretta & Orr, Inc. September 23, 2018 in Training Sessions

Think about this, for a company that's dedicated all its resources on a single new drug or product, stakes are high. So, if you haven’t even thought about tradeshows, you should learn more! Read More

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