Video Series: Planning for a Successful CAR-T IND During Early Discovery

Aug 24, 2021 - Nov 01, 2021

Virtual

Posted by Charles River Laboratories

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Add to Calendar + 2021-08-24 8:45 2021-11-01 8:00 America/New_York Video Series: Planning for a Successful CAR-T IND During Early Discovery

When developing a CAR-T oncology therapy, common failures in late-preclinical and clinical stages can be attributed to early discovery activities. Common challenges include:

  • Selecting ‘bad actor’ hits that are not developable/cause tonic signaling
  • Optimizing specificity to avoid off-target effects/immune cell activation
  • Ensuring cross-reactivity in your tox species (mouse, rat, NHP)
  • Understanding on-target/off-tumor risks and other safety liabilities in functional in vitro studies

Learn how to avoid common pitfalls and how our expertise can help guide your program to success.

Virtual

When developing a CAR-T oncology therapy, common failures in late-preclinical and clinical stages can be attributed to early discovery activities. Common challenges include:

  • Selecting ‘bad actor’ hits that are not developable/cause tonic signaling
  • Optimizing specificity to avoid off-target effects/immune cell activation
  • Ensuring cross-reactivity in your tox species (mouse, rat, NHP)
  • Understanding on-target/off-tumor risks and other safety liabilities in functional in vitro studies

Learn how to avoid common pitfalls and how our expertise can help guide your program to success.

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