Plug Into the Future of Bispecific Antibodies

Jun 20, 2023

bYlok® Bispecific Pairing Technology

Posted by Lonza

bYlok® is changing the way bispecific antibodies are designed. Achieving the correct heterodimerization of light and heavy chains during bispecific production can be challenging, and whilst the knobs-into-holes technology solves heavy chain mispairing, bYlok® offers a solution to address HC-LC mispairing.

bYlok® technology delivers >95% correct HC-LC pairing efficiency. It works on the principle of being closer-to-
nature by design, reducing the risk of any unwanted immunogenicity, whilst offering superior manufacturing

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