Overview
IVAL is proud to present our products and contract services, which represent three decades of expertise in the application of in vitro experimental systems to evaluate drug absorption, metabolism, drug-drug interactions and drug toxicity. Our forte: high-quality hepatocytes and cell culture media to support in vitro research.
In addition to the “routine” in vitro ADME studies that are offered by many contract research organizations, we have developed techniques that allow the use of hepatocytes in higher throughput screening assays to aid the selection of best drug candidates for during early phases of drug development: Organ-specific toxicity evaluation (e.g. hepatotoxicity; nephrotoxicity; neurotoxicity) using primary cells either as mono-cell type studies or as multiple organ co-cultures using our patented Integrated Discrete Multiple Organ Co-culture (IdMOC) experimental system; human hepatocyte P450 inhibition assays, and human hepatocyte P450 induction assays; as well as a comprehensive screening assay for adverse drug properties..