Nimbus Therapeutics is a biotechnology company headquartered in Cambridge, Mass., that is pioneering a new computational technology-driven paradigm to rapidly advance a diverse pipeline of novel small molecule product candidates into clinical development. We are designing highly selective and potent medicines to disrupt known drivers of serious diseases, including metabolic disease, cancer and immune-inflammatory disorders.
Nimbus’ development programs target well-characterized biological mechanisms which have proven unreachable by traditional drug development methods. Our lead targets – ACC, IRAK4, Tyk2, and KRas – were each discovered more than a decade ago, but have proven elusive to drug intervention due to limitations of potency, selectivity and pharmacokinetics in first-generation molecules.
We overcome these challenges through a deep integration of multiple disciplines, including computer-aided drug design, chemistry and pharmacology, working in close coordination with a focused network of close partners and collaborators.
For more information, go to www.nimbustx.com.