Overview

Tinker is a biopharmaceutical company engineering next-generation multimeric siRNA and ASO RNA medicines. Our proprietary FORGE™ platform creates chemically optimized, fused oligonucleotides capable of modulating multiple genetically validated targets in a single therapeutic construct, leveraging AI-enabled computational screening and design methods. We focus on complex polygenic neurological and retinal disorders where multi-targeting can uniquely address multifactorial pathology. FORGE constructs are designed to overcome limited efficacy, significant safety liabilities, cumulative toxicity, or cost and regulatory challenges present with combination or monotherapeutic approaches.