Procedure for the synthesis, deprotection and isolation of RNA using TBDMS-protected monomers

Jul 25, 2019

Application Guide

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Cleavage, deprotection and purification of synthetic oligoribonucleotides, although routine, are complex processes. No two labs seem to carry out the procedures the same way and there are many
routes to successful completion of the tasks. In the procedures here, we assume that cleavage and deprotection will occur off the synthesizer and that our TBDMS protected RNA monomers are used to manufacture the oligoribonucleotide.

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